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Keerthana, M.
- An Enhanced Speech Based Vmail for Visually Impaired People
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Affiliations
1 Department of CSE, V.R.S. College of Engineering and Technology, Arasur, Villupuram, IN
1 Department of CSE, V.R.S. College of Engineering and Technology, Arasur, Villupuram, IN
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Wireless Communication, Vol 8, No 1 (2016), Pagination: 1-5Abstract
In today's reality correspondence has turned out to be so natural because of coordination of correspondence innovations with web. However the outwardly tested individuals discover it extremely hard to use this innovation in view of the way that utilizing them requires visual observation. Voice message building design blinds individuals to get to email and other interactive media elements of working framework (tunes, text).Also in versatile application SMS can be perused by framework itself. Presently a days the headway made in PC innovation opened stages for outwardly weakened individuals over the world. This paper goes for adding to an email framework that wills even an innocent outwardly impeded individual to utilize the administrations for correspondence without past preparing. This building design will likewise diminish subjective burden taken by heedless to recall and sort characters utilizing console. This framework can be utilized by any ordinary individual likewise for instance the person who is not ready to peruse. The framework is totally taking into account intelligent voice reaction which will make it easy to understand and proficient to utilize.Keywords
IVR, Mouse Click Event, Screen Reader, Voice Mail.- Internet Usage to Access Oral Health Related Information by Patients Reporting to our Institution - A Cross Sectional Study
Abstract Views :218 |
PDF Views:105
Authors
Affiliations
1 Department of Oral Pathology, Vinayaka Mission's Sankarachariyar Dental College, Salem – 636308, Tamil Nadu, IN
2 Interns, Department of Oral Pathology, Vinayaka Mission's Sankarachariyar Dental College, Salem – 636308, Tamil Nadu, IN
1 Department of Oral Pathology, Vinayaka Mission's Sankarachariyar Dental College, Salem – 636308, Tamil Nadu, IN
2 Interns, Department of Oral Pathology, Vinayaka Mission's Sankarachariyar Dental College, Salem – 636308, Tamil Nadu, IN
Source
Journal of Academy of Dental Education, Vol 3, No 1 (2017), Pagination: 22-29Abstract
Introduction: Widespread internet usage worldwide allows increased access to medical and dental information and can be used for patient self-education.Materials and Methods: Patients who were reported to the Department of Oral Medicine of Vinayaka Missions Sankarachariyar Dental College were involved in the present study. Institutional Ethical clearance was obtained. Consent was obtained from all the participants and a Questionnaire was given to all the participants. The participants were given a list of predetermined responses to choose their answer.Results: Results were calculated. Statistical analysis was done using Chi square test and p value was calculated. Conclusion: We may conclude that creating awareness amongst people of different educational backgrounds through appropriate means (following an individualized approach based on educational qualification) would increase internet usage for acquiring information on oral health.Keywords
Dentistry, Internet Usage, Oral Health Information, Survey.References
- Harris CE, Chestnut IE. The use of the Internet to access oral health-related information by patients attending dental hygiene clinics. Int. J. Dent .Hyg. 2005 May; 3(2):70–3. https:// doi.org/10.1111/j.1601-5037.2005.00129.x PMid:16451385
- Naganandini S, Rao R, Kulkarni SB. Survey on the use of the Internet as a source of oral health information among dental patients in Bangalore City, India. Oral Health Prev Dent. 2014; 12(2):141–7. PMid:24624382
- Aydin U, Ozturk M, Kirbiyik. Prevalence of internet usage and access to health information among dental school outpatients, Telemed J. E. Health. 2004 Winter; 10(4):444–8. https://doi.org/10.1089/tmj.2004.10.444 PMid:15689648
- Fungal Biotransformation of Clobazam–Induction, Inhibition and Kinetic Studies
Abstract Views :240 |
PDF Views:83
Authors
Affiliations
1 Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam (Women’s University), Tirupathi 517 502, IN
1 Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam (Women’s University), Tirupathi 517 502, IN
Source
Current Science, Vol 118, No 4 (2020), Pagination: 603-611Abstract
The present study was aimed to explore the ability of six distinct fungi to biotransform the drug clobazam to its metabolites, and the nature of enzymes involved in such fungal biotransformation by performing screening, induction, inhibition and kinetic studies. Among the six organisms, a sample of Aspergillus fumigatus culture showed an extra peak at 3.5 min in the high performance liquid chromatography chromatogram when compared with its controls, indicating the formation of metabolite. The metabolite thus formed was confirmed by mass spectrometry and NMR spectroscopy as 4-hydroxy norclobazam. Enzyme induction and inhibition studies were conducted on the involvement of a CYP3A4-like enzyme in fungal biotransformation. Enzyme kinetic studies were conducted to determine the affinity of the enzyme to the substrate. The study revealed that A. fumigatus can be used as a microbial resource to analyse the complete metabolic profile of clobazam with a maximum concentration 30 μg/ml.Keywords
Aspergillus Fumigatus, Biotransformation, Induction, Inhibition, Kinetics.References
- Giarratano, M., Standley, K. and Benbadis S. R., Clobazam for treatment of epilepsy. Expert Opin. Pharmacother., 2012, 13, 227–233.
- DeLeon, J., Spina, E. and Diaz, F. J., Clobazam therapeutic drug monitoring: a comprehensive review of the literature with proposals to improve future studies. Ther. Drug Monit., 2013, 35, 30–47.
- Purcarin, G. and Ng, Y. T., Experience in the use of clobazam in the treatment of Lennox–Gastaut syndrome. Ther. Adv. Neurol. Disord., 2014, 7, 169–176.
- Giraud, C., Tran, A. and Rey, E., In vitro characterization of clobazam metabolism by recombinant cytochrome P450 enzymes: importance of CYP2C19. Drug Metab. Dispos., 2004, 32(11), 1279–1286.
- Freche, C., Study of an anxiolytic, clobazam, in otorhinolaryngology in psychosomatic pharyngeal manifestations. Sem. Hop. Ther., 1975, 51(4), 261–263.
- Wildin, J. D., Pleuvry, B. J., Mawer, G. E., Onon, T. and Millington, L., Respiratory and sedative effects of clobazam and clonazepam in volunteers. Br. J. Clin. Pharmacol., 1990, 29(2), 169–177.
- Venisetty, R. K. and Ciddi, V., Application of microbial biotransformation for the new drug discovery using natural drugs as substrates. Curr. Pharm. Biotechnol., 2003, 4, 123–140.
- Chen, Y., Monshouwer, M. and Fitch, W. L., Analytical tools and approaches for metabolite identification in early drug discovery. Pharm. Res., 2007, 24, 248–257.
- Beukers, R., Marx, A. F. and Zuidweg, M. H. J., Microbial conversion as a tool in the preparation of drugs. In Drug Design (ed. Ariens, E. J.), Academic Press, New York, USA, 1972, vol. 3, p. 112.
- Smith, R. V. and Rosazza, J. P., Microbial models of mammalian metabolism. J. Pharm. Sci., 1975, 64, 1737–1758.
- Smith, R. V. and Rosazza, J. P., Microbial models of mammalian metabolism. J. Nat. Prod., 1983, 46, 79–91.
- Ratna Kumara, T., Vidyavathi, M., Asha, S. and Prasad, K. V. S. R. G., Biotransformation of paracetamol by Cunninghamella echinulata. J. Pharm. Res., 2009, 8(1), 1–5.
- Barry, M. and Feely, J., Enzyme induction and inhibition. Pharmacol. Ther., 1990, 48(1), 71–94.
- Wagner, J. G., Pharmacokinetics for the Pharmaceutical Scientist, Technomic Publishing Company, Lancaster, PA, USA, 1993, vol. 14, p. 259.
- Golicnik, M., Explicit reformulations of time-dependent solution for a Michaelis–Menten enzyme reaction model. Anal. Biochem., 2010, 406, 94–96.
- Dongming Wanga, B., Hongshan, Y., Jianguo Song, B., Yufeng X. and Fengxie Jin, B., Enzyme kinetics of ginsenosidase type IV hydrolyzing 6-O-multi-glycosides of protopanaxatriol type ginsenosides. Process Biochem., 2012, 47, 133–138.
- Lin, S. K. C., Du, C., Koutinas, A., Wang, R. and Webb, C., Substrate and product inhibition kinetics in succinic acid production by Actinobacillus succinogenes. Biochem. Eng. J., 2008, 41, 128–135.
- Maria Luz, C., Michaelis and Menten and the long road to the discovery of cooperativity. FEBS Lett., 2013, 587, 2767–2771.
- Deng, X., Marjorie, P., Marie, A. T., Wafa, K., Samuel, T., Jean Marie, F. and Jean Luc, P., Similarities and differences in the biochemical and enzymological properties of the four isomaltases from Saccharomyces cerevisiae. FEBS Open Bio., 2014, 4, 200–212.
- Maria Papadovasilaki, A., Dominik Oberthur, B., Renate Gessmann, A., Iosifina Sarrou, A., Christian Betzel, B., Effie Scoulica, C. N. and Kyriacos Petratos, A. N., Biophysical and enzymatic properties of amino glycoside adenylyltransferase AadA6 from Pseudomonas aeroginosa., BB Rep., 2015, 4, 152–157.
- Azerad, R., Microbial models for drug metabolism. Adv. Biochem. Eng. Biotechnol., 1999, 63, 169–218.
- Moody, J. D., Freeman, J. P., Fu, P. P. and Cerniglia, C. E., Biotransformation of mirtazapine by Cunninghamella elegans. Drug Metab. Dispos., 2002, 30, 1274–1279.
- Moffat, A. C., In Clarke’s Identification and Isolation of Drugs (eds Jackson, J. V. et al.), Pharmaceutical Press, London, UK, 1986, 2nd edn, p. 170.
- Walzer, M., Bekersky, I., Blum, R. A. and Tolbert, D., Pharmacokinetic drug interactions between clobazam and drugs metabolized by cytochrome P450 isoenzymes. Pharmacotherapy, 2012, 32(4), 340–353.
- Yuh, L. et al., Substrate inhibition kinetics for cytochrome P450catalyzed reactions part 1. Drug Metab. Dispos., 2017, 29(4), 368–374.
- Brachet-Liermain, A., Jary, Ch., Faure, O., Guyot, M. and Loiseau, P., Liquid chromatography determination of clobazam and its major metabolite norclobazam in human plasma. Ther. Drug Monit., 1982, 4(3), 301–305.
- Sailaja, O., Aruna, R. and Durga, J., RP-HPLC Method development and validation for the estimation of clobazam in the tablet dosage form. Afro-Asian J. Sci. Technol., 2014, 1(2), 153–160.
- Effat, S., Amin Dastjani, F., Reza, A. and Mohsen, A., A stability indicating HPLC method for the determination of clobazam and its basic degradation product characterization. DARU J. Pharm. Sci., 2014, 22, 49–51.
- Segel, I. H., In Enzyme Kinetics: Behaviour and Analysis of Rapid Equilibrium and Steady State Enzyme Systems, Wiley, New York, USA, 1975, vol. 8, pp. 159–162.
- Magang, S. et al., Enzyme kinetics of cytochrome P450-mediated reactions. Curr. Drug Metab., 2000, 2, 17–36.
- Volz, M. et al., Kinetics and metabolism of clobazam in animals and man. Br. J. Clin. Pharmacol., 1979, 7, 41–50.
- Berg, J. M, Tymoczko J. L. and Stryer, L., In Biochemistry, New York W. H. Freeman, New York, USA, Section 8.4, The Michaelis–Menten model accounts for the kinetic properties of many enzymes, 5th edn, 2002; https://www.ncbi.nlm.nih.gov/books/NBK22430/.